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There are 55 real estate listings found in Wise, VA. View our Wise real estate area information to learn about the weather, local school districts, demographic data, and general information about Wise, VA. Get in touch with a Wise real estate agent who can help you find the home of your dreams in Wise. Use our mortgage calculator to see how much it would be to finance a home in Wise. Not ready to buy yet? Find and compare apartments for rent in Wise.