There are 3 real estate agents found in Irene, SD. View our Irene real estate area information to learn about the weather, local school districts, demographic data, and general information about Irene, SD. Get in touch with an Irene real estate agent who can help you find the home of your dreams in Irene. Use our mortgage calculator to see how much it would be to finance a home in Irene. Not ready to buy yet? Find and compare apartments for rent in Irene.